Selecting the Proper Elastomeric Formula

Because your drug product has direct contact with the container closure system (vial and stopper), it is critical to consider compatibility factors of the rubber formula when selecting a stopper for your drug package. It is possible for a drug product to become contaminated if the drug and components react chemically. The substances that may [...]

Impact of Steam and Gamma Processing on Elastomers

To further understand the impact of typical sterilization methods on elastomeric components, West Pharmaceutical Services, Inc. conducted a study that evaluated extractables, physical properties and functional properties of common elastomer formulations after exposure to steam and gamma irradiation. The processing of any component can have an impact on extractable profiles, physical properties and functional properties; [...]

Demystifying the Glass Blowback Feature In Pharmaceutical Container Closure Systems

Many folks in the parenteral drug business are confused about the blowback feature in glass and the no-pop ring on the elastomeric closures. Where did they come from? What are their function? What are the do’s and don’ts?  These package features are important to understand in order to select packaging materials and to avoid problems  [...]

An Alternative to Current Sterilized Plungers for Glass Syringes

The use of steam has been the preferred technique to sterilize components for sterile parenteral applications.  Steam is the most common method of sterilization for vial stoppers and related components.  However, in the case of plungers for prefillable applications, gamma irradiation has been the historic standard throughout the industry for sterilization of the elastomeric components, [...]